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Adrenomedullin Function in Vascular Endothelial Cells: Insights from Genetic Mouse Models

[ Vol. 7 , Issue. 4 ]

Author(s):

Natalie O. Karpinich, Samantha L. Hoopes, Daniel O. Kechele, Patricia M. Lenhart and Kathleen M. Caron   Pages 228 - 239 ( 12 )

Abstract:


Adrenomedullin is a highly conserved peptide implicated in a variety of physiological processes ranging from pregnancy and embryonic development to tumor progression. This review highlights past and present studies that have contributed to our current appreciation of the important roles adrenomedullin plays in both normal and disease conditions. We provide a particular emphasis on the functions of adrenomedullin in vascular endothelial cells and how experimental approaches in genetic mouse models have helped to drive the field forward.

Keywords:

Adrenomedullin, angiogenesis, endothelial, lymphangiogenesis, mouse model, permeability, CLR, RAMPs, G-protein coupled receptors, transmembrane accessory proteins, vasodilator

Affiliation:

The University of North Carolina at Chapel Hill, 111 Mason Farm Road, 6330 MBRB, Chapel Hill, North Carolina 27599.



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