Tianxin Yang Pages 199 - 209 ( 11 )
Prostaglandin E2 (PGE2) participates in blood pressure (BP) regulation through diverse mechanisms involving different tissues and different receptor subtypes. In general, PGE2 functions as a natriuretic factor in the kidney, promoting sodium excretion via inhibition of sodium transport in the distal nephron. On the other hand, PGE2 is a vasoactive agent capable of modulating vascular tone. PGE2 is a product of prostaglandin E synthase (PGES) and its biologic action is mediated by four EP receptors EP1-4 which exhibit distinct vasoactive properties. The best characterized PGES is microsomal prostaglandin E synthase-1 (mPGES-1), a viable target for the next generation of analgesic drugs. The review will focus on recent advances in understanding the roles of mPGES-1 and EP receptors in BP regulation.
mPGES-1, prostaglandin E2, blood pressure, collecting duct, angiotensin II, vasorelexation, vasoconstriction
University of Utah and VA Medical Center, 30 N 1900 E, Rm 4R312, Salt Lake City, UT 84132.