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The Role of Adipokines in Hypertension and Cardiovascular Disease

[ Vol. 3 , Issue. 3 ]

Author(s):

Andrew M. Wilson and Marno C. Ryan   Pages 208 - 215 ( 8 )

Abstract:


The prevalence of overweight (currently defined as body mass index (BMI) > 25 kg/m2) and obesity (BMI > 30 kg/m2) is rapidly increasing and has been associated with increased morbidity and mortality. Obesity is associated strongly with insulin resistance and type 2 diabetes, which are major risk factors for hypertension and cardiovascular disease. Recent evidence has emerged that adipocytes function as highly active endocrine cells and secrete a wide range of inflammatory and vaso-active agents. These include leptin and adiponectin which appear to display a range of effects on the cardiovascular system, particularly in vitro. A better understanding of the roles for these and other adiopcyte derived agents in cardiovascular disease pathogenesis may lead to the development of better prevention strategies and novel therapies.

Keywords:

Obesity, cardiovascular disease, atherosclerosis, diabetes, hypertension, inflammation

Affiliation:

Falk Cardiovascular Institute, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA.



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