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New Genetic Polymorphisms as an Epidemiological Factor of Arterial Hypertension in Patients with Hyposodical Diet

Author(s):

Sabina López-Toledo, Sergio A. Ramírez-García*, Carlos E. Cabrera-Pivaral, Luis Javier Flores-Alvarado, Dalia Madrigal Ruiz, María E. Aguilar Aldrete and Felipe Parada-Luna   Pages 1 - 5 ( 5 )

Abstract:


Hypertension is a major public health problem, affecting more than a quarter of the world's population that causes serious cardiovascular problems. In recent years, different polymorphisms have been studied and helped to identify some candidate genes and hereditary syndromes associated to the molecular mechanisms involved in the development of hypertension. Therefore, it is important to identify these molecular mechanisms. This review exposes all the genes and polymorphisms that increase or decrease the risk of hypertension in different populations that are related to the renin angiotensin aldosterone system, G protein, salt excretion, aldosterone synthesis, lipid metabolism, mechanism of insulin resistance, vitamin metabolism, purines and sodium reabsorption. This document can be a useful tool in clinical practice, in addition to serving as a support for future research on this topic.

Keywords:

Genetics, hypertension, polymorphism, epigenomics, epidemiology, haplotypes.

Affiliation:

Instituto de Nutrición, Universidad de la Sierra Sur. Miahuatlán de Porfirio Díaz, Oaxaca, Instituto de Nutrición, Universidad de la Sierra Sur. Miahuatlán de Porfirio Díaz, Oaxaca, Departamento de Salud Pública, Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara, Jalisco, Deparatmemnto de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara, Jalisco, Departamento de Fisiología, Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara, Jalisco, Departamento de Salud Pública, Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara, Jalisco, Programa de Maestría en Salud Pública, Universidad de la Sierra Sur. Miahuatlán de Porfirio Díaz, Oaxaca



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