Alejandro Díaz*, Ariel Pascaner, Sandra Wray and Edmundo Cabrera Fischer Pages 1 - 12 ( 12 )
Background: The relationship between the increases in pulse pressure (PP) and arterial stiffness determined by aging or systemic hypertension has been widely reported. These findings are supported by large-cohort analyzes conducted in well-known populations, such as Framingham Study. However, there is evidence that an age-PP curvilinear relationship may exist in hypertensive subjects. This study aimed to evaluate the age-related change in pulse pressure and arterial stiffness in a population-based study.
Methods: Carotid-femoral Pulse Wave Velocity (cfPWV) were obtained in 2075 subjects.
Results: Age-related changes of PP showed a curvilinear relationship (R=0.39, p<0.0001) in normotensive subjects, with a nadir at around 50 years of age. On the other hand, the age-cfPWV relationship showed a linear and positive correlation (R=0.72, p<0.0001). PP also showed a curvilinear relationship with age (R=0.36, p<0.0001) in hypertensive subjects, with a nadir around 50 years of age. The age-cfPWV relationship showed a linear and positive correlation (R=0.55, p<0.0001). Similar results were observed in the adult population (age≥16 years). Multivariate analysis showed that age, sex, cfPWV, and mean arterial pressure are determinants of PP values in the entire population; however, this result was not uniform when different subgroups were analyzed.
Conclusion: In conclusion, age-related changes in PP showed a curvilinear relationship and no parallelism with the age-cfPWV relationship for both normotensive and hypertensive subjects. The determinants of PP impact it differently depending on age and the pathological condition of the subject.
pulse pressure, pulse wave velocity, arterial stiffness, ageing.
Instituto de Investigación en Ciencias de la Salud, UNICEN-CONICET, Tandil,, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMTTYB) – CONICET-UF, Buenos Aires,, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMTTYB) – CONICET-UF, Buenos Aires,, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMTTYB) – CONICET-UF, Buenos Aires