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Role of Lactate Dehydrogenase in the Prediction of Severity in Pre- Eclampsia

[ Vol. 16 , Issue. 3 ]

Author(s):

Feriha F. Khidri*, Fozia Shaikh, Imran-ul-Hassan Khowaja and Hina Riaz   Pages 223 - 228 ( 6 )

Abstract:


Background: Pre-eclampsia is a hypertensive pregnancy disorder accompanied by proteinuria. Serum Lactate Dehydrogenase (LDH) is a biochemical marker that reflects the severity and progression of pre-eclampsia.

Methods: A cross-sectional study was conducted at the Liaquat University of Medical and Health Sciences (LUMHS). One hundred pre-eclamptic women were enrolled and categorized into mild (n=30) and severe pre-eclamptic groups (n=70) to ascertain the function of LDH as a prognostic marker and to assess its association with severity and gestational age in pre-eclamptic women.

Results: The significant differences in mean concentrations of LDH between mild and severe preeclamptic women (p-value <0.0001) and early and late-onset pre-eclamptic women (p-value=0.049) were found. Significant differences were also found in the LDH range between mild and severe preeclamptic women presented with late-onset pre-eclampsia (p-value= 0.004). Statistically significant differences (p-value= 0.019) in the levels of LDH were found with systolic blood pressure and proteinuria (p-value= 0.048).

Conclusion: LDH is the prognostic marker representing the severity of pre-eclampsia. An increased level of LDH directs adequate monitoring and management; and by early detection of preeclampsia, serious consequences and complications may be prevented.

Keywords:

Blood pressure, gestational age, LDH, proteinuria, pre-eclampsia, severity, hypertensive pregnancy disorder.

Affiliation:

Department of Biochemistry, Molecular Biology and Genetics, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Biochemistry Department, Liaquat University of Medical and Health Sciences, Jamshoro, Biochemistry Department, Liaquat University of Medical and Health Sciences, Jamshoro, Physiology Department, Liaquat University of Medical and Health Sciences, Jamshoro

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