McCall Walker, Paras Patel, Osung Kwon, Ryan J Koene, Daniel A. Duprez and Younghoon Kwon* Pages 1 - 12 ( 12 )
Hypertension is one of the most well-established risk factors for atrial fibrillation. Long-standing untreated hypertension leads to structural remodeling and electrophysiologic alterations causing an atrial myopathy that forms a vulnerable substrate for the development and maintenance of atrial fibrillation. Hypertension-induced hemodynamic, inflammatory, hormonal, and autonomic changes all appear to be important contributing factors. Furthermore, hypertension is also associated with several atrial fibrillation-related comorbidities. As such, hypertension may represent an important target for therapy in atrial fibrillation. Clinicians should be aware of pitfalls of the blood pressure measurement in atrial fibrillation. While the auscultatory method is preferred, the use of automated devices appears to be an acceptable method in the ambulatory setting. There are pathophysiologic bases and emerging clinical evidence suggesting the benefit of renin-angiotensin system inhibition in risk reduction of atrial fibrillation development particularly in patients with left ventricular hypertrophy or left ventricular dysfunction. A better understanding of hypertension’s pathophysiologic link to atrial fibrillation may lead to the development of novel therapies for the primary prevention of atrial fibrillation. Finally, future studies are needed to address optimal blood pressure goal to minimize the risk of atrial fibrillation-related complications.
Atrial Fibrillation, Hypertension, Blood Pressure, Renin-angiotensin System, Atrial Remodeling, Autonomic Dysfunction, Chronic Inflammation
Department of Medicine, University of Virginia, Charlottesville, VA, Department of Medicine, University of Virginia, Charlottesville, VA, Division of Cardiology, Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Uslan, Seoul, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio OH, Department of Medicine, University of Minnesota, Minneapolis MN, Department of Medicine, University of Virginia, Charlottesville, VA