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Pharmacological Treatment of Hypertension: Effects in Endothelial Function

[ Vol. 14 , Issue. 2 ]


Leonardo Cobos-Segarra*, Patricio Lopez-Jaramillo, Carlos Ponte-Negretti CI, Raul Villar and Ernesto Penaherrera   Pages 123 - 127 ( 5 )


The vascular endothelium plays an important role to maintain the functional integrity of the cardiovascular system. The synthesis and secretion of substances with biological activity such as prostacyclin and NO give endothelium the vasodilator, antithrombotic, and antiatherosclerotic properties. Endothelial dysfunction participates in the genesis of HTA, but also hypertension produces endothelial damage. The major class of antihypertensive drugs has beneficial effects in the recuperation of the endothelial function, actions that are contributing to explain the impact of the adequate control of HTA in the reduction of CV events.


Hypertension, endothelial function, cardiovascular system, biological activity, HTA, antihypertensive drugs.


Unidad de Cardiologia, Hospital El Pino, Santiago, Direccion de Investigaciones, FOSCAL, Bucaramanga, Colombia and Facultad de Ciencias de la Salud Eugenio Espejo, UTE, Quito, Fundacion Venezolana de Cardiología Preventiva, Caracas, Departamento de Medicina Interna, Seccion Enfermedades Cardio Metabolicas, La Serena, Servicio de Cardiologia, Hospital Luis Vernaza de Guayaquil

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