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Effect on Morphology, Osmotic Fragility and Electro Kinetic Potential of Erythrocytes in Hypertension

[ Vol. 13 , Issue. 2 ]

Author(s):

S.S. Gaikwad* and J. G. Avari*   Pages 132 - 137 ( 6 )

Abstract:


Background: Hypertension is a common health problem concerning a large proportion of population and a leading global risk factor for the burden of cardiovascular disease (CVD). The purpose of this study was to assess the efficacy of the erythrocyte zeta potential as a potential additional indicator for cardiovascular disorder risk so that patients with this can be more rapidly identified and treated.

Methods: In the present study, blood samples were collected in 5% dextrose solution from patients suffering from hypertension and healthy volunteers (Not taken any medication). The mobility of individual RBCs was tracked by equipped Zeta meter-ZM4DAQ software using microscopicallyacquired video images, data were recorded 10 times for each sample and average zeta-potential in mv was recorded.

Results: We found that mean erythrocytic ZP of control group was found to be 23.41 mv (± 1.87) whereas, erythrocytic ZP for Hypertensive patients was found to be 16.05 (±1.72) mV and Hypertensive patients with Diabetes is much lower from 6.96 mV to 22.76 (+3.88) mV along with structural deformities and increased osmotic fragility of erythrocytes.

Conclusion: The data suggest that there are morphological changes in erythrocyte structure, increased osmotic fragility along with significantly lower ZP value as compared to that of healthy volunteers which may be the major cause for progression to the development of cardiovascular disease.

Keywords:

Hypertension, red blood cells (RBCs), diabetes mellitus(DM), osmotic fragility, erythrocytes, electrochemical property, zeta potential.

Affiliation:

Department of Pharmaceutical Sciences, R. T. M. Nagpur University, Mahatma, Jyotiba Fuley Educational Campus, Amravati Road, Nagpur, 440033, Maharashtra, Department of Pharmaceutical Sciences, R. T. M. Nagpur University, Mahatma, Jyotiba Fuley Educational Campus, Amravati Road, Nagpur, 440033, Maharashtra

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